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Anti-Hu CD226 APC

CD226 is a type I transmembrane glycoprotein, which is expressed after activation on NK cells, platelets, monocytes, and some T cells. Its expression is increased in patients suffering from some autoimmune diseases or viral infections. CD226 is being phosphorylated on its cytoplasmic tail and interacts with LFA-1 complex (CD11a/CD18), resulting in calcium-independent intercellular contacts. Ligands for CD226 are CD155 and CD112.

Product Specifications

Certification

RUO

Target Antigen

CD226

Clone

11A8

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Fourcade J, Sun Z, Chauvin JM, Ka M, Davar D, Pagliano O, Wang H, Saada S, Menna C, Amin R, Sander C, Kirkwood JM, Korman AJ, Zarour HM: CD226 opposes TIGIT to disrupt Tregs in melanoma. JCI Insight. 2018 Jul 26;3 (14) :e121157. , URL: https://pubmed.ncbi.nlm.nih.gov/30046006/, *Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M: Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155) . J Immunol. 2004 Apr 1;172 (7) :3994-8., URL: https://pubmed.ncbi.nlm.nih.gov/15034010/, *Deuss FA, Watson GM, Goodall KJ, Leece I, Chatterjee S, Fu Z, Thaysen-Andersen M, Andrews DM, Rossjohn J, Berry R: Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1. J Biol Chem. 2019 Aug 16;294 (33) :12534-12546., URL: https://pubmed.ncbi.nlm.nih.gov/31253644/, *Deng C, Li W, Fei Y, Wang L, Chen Y, Zeng X, Zhang F, Li Y: Imbalance of the CD226/TIGIT immune checkpoint is involved in the pathogenesis of primary biliary cholangitis. Front Immunol. 2020 Jul 24;11:1619., URL: https://pubmed.ncbi.nlm.nih.gov/32793241/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 11A8 recognizes an extracellular epitope within CD226 transmembrane glycoprotein.

Applications Notes

6

Species

Non-human primates, Human

CAS Number

9007-83-4

Isotype

Mouse IgG1 kappa

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