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PCSK9-IN-27

PCSK9-IN-27 (Compound 108) is a PCSK9 inhibitor (IC50: 3.4 nM) . PCSK9-IN-27 reduces LDLR degradation and increases LDL-C uptake[1].

Product Specifications

UNSPSC

12352005

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pcsk9-in-27.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C=CC=C1Cl)C2=CN=C(N[C@@H]3C[C@@H](NC4=CN=C(C5CC5)C=N4)CC3)C=C2

Molecular Formula

C22H23ClN6O

Molecular Weight

422.91

References & Citations

[1]Gavin Donal O’MAHONY, et al. Pcsk9 inhibitors and methods of use thereof. Patent. WO2024062089A1

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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