(Rac) -Hesperetin-13C, d3

(Rac) -Hesperetin-13C, d3 is the 13C- and deuterium labeled (Rac) -Hesperetin. (Rac) -Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

Product Specifications

CAS Number

[2750534-85-9]

UNSPSC

12352005

Target

Apoptosis; Autophagy; Isotope-Labeled Compounds; p38 MAPK

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway; Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Purity

99.3

Solubility

10 mM in DMSO

Smiles

O=C1CC(C2=CC=C(O[13C]([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C15 13CH11D3O6

Molecular Weight

306.29

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964|[3]Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.|[4]Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39 (12) :2052-2059.|[5]Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301