ST-1892

ST-1892 (compound 14) is a highly potent FXR agonist (EC50=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation[1].

Product Specifications

CAS Number

[1409411-32-0]

UNSPSC

12352005

Target

FXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/st-1892.html

Smiles

O=C(C1=CC=CC(C2=NC(C3=CC=CC=C3C)=NO2)=C1)O

Molecular Formula

C16H12N2O3

Molecular Weight

280.28

References & Citations

[1]Flesch D, et al. Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties[J]. Bioorganic & medicinal chemistry, 2015, 23 (13) : 3490-3498.