5-Vinyl-2'-deoxyuridine

5-Vinyl-2'-deoxyuridine (5-VINYL-DURD), a thymidine analogue, is incorporated into cellular DNA during DNA replication. 5-Vinyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and induces DNA damage leads to apoptosis in human cultured cells[1].

Product Specifications

CAS Number

[55520-67-7]

Product Name Alternative

5-VINYL-DURD

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-vinyl-2-deoxyuridine.html

Purity

97.0

Smiles

O[C@H]1C[C@H](N2C(NC(C(C=C)=C2)=O)=O)O[C@@H]1CO

Molecular Formula

C11H14N2O5

Molecular Weight

254.24

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yizhu Li, et al. DNA templated Click Chemistry via 5-vinyl-2'-deoxyuridine and an acridine-tetrazine conjugate induces DNA damage and apoptosis in cancer cells. Life Sci. 2023 Oct 1:330:122000.