STING agonist-26
Product Specifications
UNSPSC Description
STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].
Target Antigen
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/sting-agonist-26.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CN=C3N2C/C=C/CN4C5=C(OCCCN6CCNCC6)C=C(C(N)=O)C=C5N=C4NC(C7=CC(C)=NN7CC)=O
Molecular Weight
819.91
References & Citations
[1]Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152959/STING-agonist-26-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152959/STING-agonist-26-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2868261-48-5
Available Sizes
Curated Selection
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