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GNE-371

GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1 (2) .

Product Specifications

CAS Number

[1926986-36-8]

UNSPSC

12171500

Target

DNA/RNA Synthesis

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GNE-371.html

Purity

98.21

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(NC=C2)=C2C(C3=C4N=CN(C)C4=CC(C(N5CCOCC5)=O)=C3)=CN1CCC=C

Molecular Formula

C24H25N5O3

Molecular Weight

431.49

References & Citations

[1]Wang S, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem. 2018 Oct 25;61 (20) :9301-9315.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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