HCAIX-IN-20
HCAIX-IN-20 (compound APBS-5m) is a potent inhibitor of carbonic anhydrase IX (hCA IX), with the Ki of 2.7 nM. hCAIX-IN-20 plays an important role in cancer research[1].
Product Specifications
CAS Number
3047054-26-9
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-20.html
Smiles
ClC1=C(Cl)C(C2=C(C#N)C(O)=NC(SCC(NC3=CC=C(S(N)(=O)=O)C=C3)=O)=N2)=CC=C1
Molecular Formula
C19H13Cl2N5O4S2
Molecular Weight
510.37
References & Citations
[1]Salma M Hefny, et al. A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments. Eur J Med Chem. 2024 Aug 5:274:116527.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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