Anti-MMP12 Antibody [SR03-23]

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

EC 3.4.24.65 antibody HME antibody Macrophage elastase antibody Macrophage metalloelastase antibody Macrophage metaloelastase antibody Matrix metallopeptidase 12 (macrophage elastase) antibody Matrix metalloprotease 12 antibody Matrix metalloproteinase-12 antibody ME antibody MGC138506 antibody MME antibody MMP 12 antibody MMP-12 antibody Mmp12 antibody MMP12_HUMAN antibody

Abbreviation

MME, ME, hME, MMP-12

Swiss Prot

P39900 Human; P34960 Mouse; Q63341 Rat

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within Human MMP12 aa 421-470 / 470.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

A549 cell lysate, Hela cell lysate, MCF-7 cell lysate, THP-1 cell lysate, human breast carcinoma tissue lysate, mouse lung tissue lysate, rat lung tissue lysate.