Anti-JNK1+JNK2+JNK3 Antibody [SA43-06]
The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). Each gene is expressed as either 46 kDa or 55 kDa protein kinases, depending upon how the 3' coding region of the corresponding mRNA is processed. There have been no functional differences documented between the 46 kDa and the 55 kDa isoform, however, a second form of alternative splicing occurs within transcripts of JNK1 and JNK2, yielding JNK1-α, JNK2-α and JNK1-β and JNK2-β. Differences in interactions with protein substrates arise because of the mutually exclusive utilization of two exons within the kinase domain. and JNK2 are found in all cells and tissues. JNK3 is found mainly in the brain, but is also found in the heart and the testes.
Product Specifications
Product Name Alternative
Abbreviation
MAP kinase 8/9/10, MAPK 8/9/10, SAPK1c/a/b
Swiss Prot
P45983 Human; P45984 Human; P53779 Human; Q61831 Mouse; Q91Y86 Mouse; Q9WTU6 Mouse; P49185 Rat; P49186 Rat; P49187 Rat
Cellular Locus
Cytoplasm, Nucleus, Membrane, Mitochondrion
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Cow,Monkey,Zebrafish
Immunogen
Recombinant protein within Human JNK1 aa 1-423 / 427.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IF-Tissue, IHC-P, IP
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:50 ;IF-Tissue: 1:50 ;IHC-P: 1:400 ;IP: Use at an assay dependent concentration.
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 48/53 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
True
CAS Number
9007-83-4
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