Calpain 1 Rabbit Polyclonal Antibody

Calpain 1, also designated ?-calpain, is an intracellular calcium-dependent protease that cleaves cyto-skeletal and submembranous proteins. Calpains are nonlysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+-dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain-1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Ca2 activated neutral protease antibody Calcium activated neutral proteinase antibody Calcium activated neutral proteinase small subunit antibody Calcium dependent protease small subunit 1 antibody Calcium dependent protease small subunit antibody Calcium-activated neutral proteinase 1 antibody Calpain 1 antibody Calpain 1 large subunit antibody Calpain 1, (mu/I) large subunit antibody Calpain mu type antibody Calpain mu-type antibody Calpain regulatory subunit antibody Calpain small subunit 1 antibody Calpain, large polypeptide L1 antibody Calpain-1 catalytic subunit antibody Calpain-1 large subunit antibody CAN1_HUMAN antibody CANP 1 antibody CANP antibody CANP small subunit antibody CANP1 antibody CANPL 1 antibody CANPL1 antibody CAPN 1 antibody CAPN1 antibody Cell proliferation inducing protein 30 antibody Cell proliferation-inducing gene 30 protein antibody Micromolar Calpain antibody Micromolar-calpain antibody Mu Calpain antibody muCANP antibody muCL antibody

Abbreviation

CANP 1, muCANP, CAPN1, CANPL1, PIG30

Swiss Prot

P07384 Human, O35350 Mouse, P97571 Rat

Cellular Locus

Cytoplasm. Cell membrane.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant protein within Human Calpain 1 aa 293-519 / 714.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

HUVEC, MCF-7, human tonsil tissue, human kidney tissue, 2 kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 82 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Curated Selection

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