PKM2 Rabbit Polyclonal Antibody

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival . Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

CTHBP antibody Cytosolic thyroid hormone binding protein antibody Cytosolic thyroid hormone-binding protein antibody KPYM_HUMAN antibody MGC3932 antibody OIP 3 antibody OIP-3 antibody OIP3 antibody OPA interacting protein 3 antibody Opa-interacting protein 3 antibody p58 antibody PK muscle type antibody PK, muscle type antibody PK2 antibody PK3 antibody PKM antibody PKM2 antibody pykm antibody Pyruvate kinase 2/3 antibody Pyruvate kinase 3 antibody Pyruvate kinase isozymes M1/M2 antibody Pyruvate kinase muscle antibody Pyruvate kinase muscle isozyme antibody pyruvate kinase PKM antibody Pyruvate kinase, muscle 2 antibody TCB antibody THBP1 antibody Thyroid hormone binding protein 1 antibody Thyroid hormone binding protein cytosolic antibody Thyroid hormone-binding protein 1 antibody Tumor M2 PK antibody Tumor M2-PK antibody

Abbreviation

Pyruvate kinase PKM,Cytosolic thyroid hormone-binding protein CTHBP Opa-interacting protein 3 OIP-3 Pyruvate kinase 2/3 Pyruvate kinase muscle isozyme Thyroid hormone-binding protein 1 THBP1 Tumor M2-PK p58 PKM

Swiss Prot

P14618 Human, P52480 Mouse, P11980 Rat

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant protein corresponding to C terminal of Human PKM2 .

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

MDA-MB-231 cell lysate, SiHa cell lysate, NIH/3T3 cell lysate, Rat heart tissue lysate, Rat skeletal muscle tissue lysate, A549, NIH/3T3, PC-12, human lung cancer tissue, human testis tissue, mouse testis tissue, rat testis tissue.