TCF7L2/TCF4 Rabbit Polyclonal Antibody
TCF7L2 is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions within the cell. It is a member of the Wnt signaling pathway. Stimulation of the pathway leads to the association of β-catenin with BCL9, translocation to the nucleus, and association with TCF7L2, which in turn results in the activation of Wnt target genes, specifically repressing proglucagon synthesis in enteroendocrine cells. TCF7L2 is implicated in a large variety of diseases. Several single nucleotide polymorphisms are associated with type 2 diabetes. In European populations it was found to be a major determinant of type 2 risk. A frameshift mutation of TCF7L2 is implicated in colorectal cancer .Variants of the gene are most likely involved in many other cancer types
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
T-cell factor 4,TCF-4,hTCF-4
Swiss Prot
Q9NQB0 Human, Q924A0 Mouse, D3Z9D1 Rat
Cellular Locus
Nucleus
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within N-terminalHuman TCF4 aa 1-50 / 619.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
Hela, HepG2, HCT116, SW480, rat kidney tissue, human tonsil tissue, human colon cancer tissue, human breast cancer tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000;IF-Cell: 1:500-1:2,000;IHC-P: 1:100-1:500;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 68 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
SERPINC1 (Antithrombin-III, Serpin Peptidase Inhibitor, Clade C (Antithrombin), Member 1)
