DPY30 Rabbit Polyclonal Antibody
As part of the MLL1/MLL complex, DPY30 is involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. DPY30 may play some role in histone H3 acetylation. In a teratocarcinoma cell, it plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. DPY30 may also play an indirect or direct role in endosomal transport. In the recent study, it showed that depletion of Dpy-30 does not affect ESC self-renewal, but significantly alters the differentiation potential of ESCs, particularly along the neural lineage.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Dpy-30-like protein antibody Dpy-30L antibody DPY30 antibody DPY30_HUMAN antibody HDPY-30 antibody Protein dpy-30 homolog antibody Saf19 antibody
Abbreviation
Dpy-30L
Swiss Prot
Q9C005 Human, Q99LT0 Mouse
Cellular Locus
Nucleus. Golgi apparatus
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Full length protein.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IF-Cell, IHC-P
Positive Control
NCCIT , F9, D3, human lung carcinoma tissue, mouse brain tissue.
Concentration
1 mg/mL
Dilution
IHC-P: 1:100-1:200 ;IF-Cell: 1:100-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 11kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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