PRDM14 Rabbit Polyclonal Antibody
PR domain zinc finger protein 14 is a transcription factor that has both positive and negative roles on transcription. It is expressed in embryonic stem cells and tends to be overexpressed in breast cancer. PRDM14 is required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. It may play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. PRDM14 directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
PRDM14
Swiss Prot
Q9GZV8 Human
Cellular Locus
Nucleus
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human PRDM14 aa 1-250 / 571.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Human embryonic stem cells, human lung, MCF-7
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IF-Cell:1:100;IHC-P: 1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
~64kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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