p53 Rabbit Polyclonal Antibody
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. P53 is found in increased amounts in a wide variety of transformed cells. P53 is frequently mutated or inactivated in about 60% of cancers.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
TP53
Swiss Prot
P04637 Human
Cellular Locus
Cytoplasm, Nucleus, Cytoskeleton, Endoplasmic reticulum, Mitochondrion.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within C-terminal human P53.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell
Positive Control
MDA-MB-231 cell lysate, HEK-293 cell lysate, MDA-MB-468 cell lysate, A431.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 53 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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