HDAC3 Mouse Monoclonal Antibody [B2-G9]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
HD3
Swiss Prot
O15379 Human, O88895 Mouse, Q6P6W3 Rat
Cellular Locus
Cytosol, Nucleus, Cytoplasm.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within C-terminal human HDAC3.
Isotype
IgG2b
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
MCF-7 lysate, PC-12 cell lysate, MCF-7, human kidney tissue, mouse kidney tissue, Hela.
Concentration
2 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
49 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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