Cathepsin B Mouse Monoclonal Antibody [J11-A11]
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. A wide array of diseases results in elevated levels of cathepsin B, which causes numerous pathological processes including cell death, inflammation, and production of toxic peptides. Focusing on neurological diseases, cathepsin B gene knockout studies in an epileptic rodent model have shown cathepsin B causes a significant amount of the apoptotic cell death that occurs as a result of inducing epilepsy. Mutations in the CTSB gene have been linked to tropical pancreatitis, a form of chronic pancreatitis
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
CTSB, CPSB
Swiss Prot
P07858 Human, P10605 Mouse, P00787 Rat
Cellular Locus
Lysosome, Melanosome, Secreted, Apical cell membrane.
Host
Mouse
Species Reactivity
Human,Zebrafish,Mouse,Rat
Immunogen
Synthetic peptide within human Cathepsin B aa 300-338/338.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
RAW264.7 cell lysate, PC-12 cell lysate, SW480 cell lysates, SW480.
Concentration
2 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:50
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 38 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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