Lin28A Mouse Monoclonal Antibody [A4-A6]
LIN28A is conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs. LIN28A is localized to the periendoplasmic reticulum (ER) area and inhibits translation of mRNAs that are destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Overexpression of LIN28A, in conjunction with Oct-4, Sox2, and Nanog, can reprogram human fibroblasts to pluripotent, ES-like cells.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Lin-28A
Swiss Prot
Q9H9Z2 Human, Q8K3Y3 Mouse
Cellular Locus
Cytoplasm, Nucleus.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within human Lin28A aa 1-209/209.
Isotype
IgG2b
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
NCCIT cell lysate, F9 cell, human kidney cancer tissue.
Concentration
2 mg/mL
Dilution
WB: 1:10,000 ;IF-Cell: 1:100 ;IHC-P: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 23 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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