FAM3A Mouse Monoclonal Antibody [7-B9]
The FAM3 gene family is a novel cytokine-like gene family, which includes four members designated as FAM3A, FAM3B, FAM3C, and FAM3D. FAM3A is a secreted protein belonging to the FAM3 family of four alpha -helix bundle cytokines. It is expressed in multiple tissues. Mature human FAM3A shares approximately 93% amino acid sequence identity with the mouse and rat protein.FAM3A belongs to a novel cytokine-like gene family, and its physiological role remains largely unknown. FAM3A activated Akt through the p110α catalytic subunit of PI3K in an insulin-independent manner. Blockade of P2 ATP receptors or downstream phospholipase C (PLC) and IP3R and removal of medium calcium all significantly reduced FAM3A-induced increase in cytosolic free Ca2+ levels and attenuated FAM3A-mediated PI3K/Akt activation. Moreover, FAM3A-induced Akt activation was completely abolished by the inhibition of calmodulin (CaM).
Product Specifications
Product Name Alternative
Abbreviation
FAM3A, 2-19, 2.19
Swiss Prot
P98173 Human, Q9D8T0 Mouse,
Cellular Locus
Secreted.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human FAM3A 1-230 / 230.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Rat smooth muscle tissue lysates, human kidney tissue, human fetal skeletal muscle tissue, mouse heart tissue, A431.
Concentration
2 mg/mL
Dilution
WB: 1:2,000-1:5,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 25 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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