SCAI Mouse Monoclonal Antibody [7-A4]
Protein SCAI, also known as Suppressor of cancer cell invasion protein, and encoded by the gene name SCAI, is a tumor suppressor that suppresses MKL1-induced SRF transcriptional activity. It is a regulator of cell migration and appears to be involved in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. SCAI localizes in the nucleus, where it binds and inhibits the myocardin-related transcription factor MAL by forming a ternary complex with serum response factor (SRF).
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
SCAI
Swiss Prot
Q8N9R8 Human
Cellular Locus
Membrane. Nucleus. Cytoplasm.
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within Human SCAI aa 1-606 / 606.
Isotype
IgM
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:1,000-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:400
Purity
Protein L affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 70 kDa
Storage Conditions
Store at -20°C. Stable for 12 months from date of receipt.
Recombinant Antibody
No
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