Human IgG heavy chain Mouse Monoclonal Antibody [54-76]
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .
Product Specifications
Product Name Alternative
Abbreviation
igg
Swiss Prot
P01857 Human, P01859 Human, P01860 Human, P01861 Human
Cellular Locus
Cell membrane, Immunoglobulin, Membrane, Secreted.
Host
Mouse
Species Reactivity
Human
Immunogen
Native protein.
Isotype
IgG2a
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, ELISA
Positive Control
Human IgG protein lysates.
Concentration
2 mg/mL
Dilution
WB: 1:5,000 ;ELISA: 1:5,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
50 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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