PRPF4 Recombinant Rabbit Monoclonal Antibody [JE65-37]
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PRPF4
Swiss Prot
O43172 Human
Cellular Locus
Nucleus, Nucleus speckle.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human PRPF4 aa 1-50/522.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
HT-29 cell lysate, SW480 cell lysate, MCF-7 cell lysate, SiHa, human cervical carcinoma tissue, human colon tissue, H1395.
Concentration
1 mg/mL
Dilution
WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:100-1:400
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 58 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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