RSK2 Recombinant Rabbit Monoclonal Antibody [JE63-19]

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

90 kDa ribosomal protein S6 kinase 3 antibody CLS antibody HU 3 antibody HU2 antibody HU3 antibody Insulin stimulated protein kinase 1 antibody Insulin-stimulated protein kinase 1 antibody ISPK-1 antibody ISPK1 antibody KS6A3_HUMAN antibody MAP kinase activated protein kinase 1b antibody MAP kinase-activated protein kinase 1b antibody MAPK activated protein kinase 1b antibody MAPK-activated protein kinase 1b antibody MAPKAP kinase 1b antibody MAPKAPK 1b antibody MAPKAPK-1b antibody MAPKAPK1B antibody Mental retardation, X linked 19 antibody MRX19 antibody OTTHUMP00000023036 antibody p90 RSK2 antibody p90 RSK3 antibody p90-RSK 3 antibody p90RSK3 antibody pp90RSK2 antibody Ribosomal protein S6 kinase 90kDa polypeptide 3 antibody Ribosomal protein S6 kinase alpha 3 antibody Ribosomal protein S6 kinase alpha-3 antibody Ribosomal protein s6 kinase ii alpha 2 antibody Ribosomal S6 kinase 2 antibody Rps6ka3 antibody RSK antibody RSK-2 antibody RSK2 antibody S6 kinase 2 antibody S6K alpha3 antibody S6K-alpha-3 antibody

Abbreviation

RPS6KA3

Swiss Prot

P51812 Human, P18654 Mouse,

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within human RSK2 aa 661-710/740.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

NIH/3T3 cell lysate, MCF-7 cell lysate, rat lung tissue lysates, human tonsils tissue, human liver carcinoma tissue, human colon carcinoma tissue, human skin tissue, human prostate tissue, human breast tissue, human breast carcinoma tissue, human pancreas tissue, mouse brain tissue, HepG2.