AMSH Recombinant Rabbit Monoclonal Antibody [JE63-41]
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
STAMBP
Swiss Prot
O95630 Human
Cellular Locus
Cytoplasm, Endosome, Membrane, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human AMSH aa 151-200/424.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
MCF-7 cell lysate, 293T cell lysate, HepG2 cell lysate, Hela cell lysate, SW480 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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