WDR41 Mouse Monoclonal Antibody [A9C10]
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy 1, 2, 3, 4. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation 5. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
WDR41, MSTP048
Swiss Prot
Q9HAD4 Human,
Cellular Locus
Cytoplasm.
Host
Mouse
Species Reactivity
Human,Rat
Immunogen
Recombinant protein within human aa 231-430 / 459.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
Daudi cell lysate, SiHa cell lysate, rat kidney tissue, human testis tissue, human colon tissue, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:1,000;IHC-P: 1:1,000;IF-Cell: 1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 52 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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