FIP200 Mouse Monoclonal Antibody [A9A10]

FIP200 (FAK family kinase-interacting protein of 200 kDa) was identified in a two-hybrid screen with the tyrosine kinase Pyk2 and can inhibit Pyk2 kinase activity as well as related family members. FIP200 was later independently identified in a multi-drug resistance screen and named RB1CC1 (RB1-inducible coiled-coil 1) due to its induction by cytotoxic stress and RB1 expression regulation. FIP200 function has been linked to apoptosis, cell cycle progression, cell growth, and migration. FIP200 has also recently been shown to interact with ULK1 and is required for autophagosome formation. FIP200 is part of an ULK1 complex along with Atg13 that is regulated by mTOR and is required for starvation induced autophagy.