AMPK alpha 2 Mouse Monoclonal Antibody [A6A10]
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
PRKAA2
Swiss Prot
P54646 Human, Q8BRK8 Mouse, Q09137 Rat
Cellular Locus
Nucleus, Cytoplasm.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human AMPK alpha 2 aa 231-430.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:500 ;IF-Cell: 1:50 ;IHC-P: 1:100-1:500
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 62 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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