PSMA Mouse Monoclonal Antibody [A5G5]

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Cell growth inhibiting protein 27 antibody Cell growth-inhibiting gene 27 protein antibody FGCP antibody Folate hydrolase (prostate-specific membrane antigen) 1 antibody Folate hydrolase 1 antibody Folate hydrolase antibody Folate hydrolase prostate specific membrane antigen 1 antibody FOLH 1 antibody FOLH antibody Folh1 antibody FOLH1_HUMAN antibody Folylpoly gamma glutamate carboxypeptidase antibody Folylpoly-gamma-glutamate carboxypeptidase antibody GCP 2 antibody GCP II antibody GCP2 antibody GCPII antibody GIG27 antibody Glutamate carboxylase II antibody Glutamate carboxypeptidase 2 antibody Glutamate carboxypeptidase II antibody Membrane glutamate carboxypeptidase antibody mGCP antibody N acetylated alpha linked acidic dipeptidase 1 antibody N-acetylated-alpha-linked acidic dipeptidase I antibody NAALAD 1 antibody NAALAD1 antibody NAALAdase antibody NAALADase I antibody Prostate specific membrane antigen antibody Prostate specific membrane antigen variant F antibody Prostate-specific membrane antigen antibody PSM antibody PSMA antibody Pteroylpoly gamma glutamate carboxypeptidase antibody Pteroylpoly-gamma-glutamate carboxypeptidase antibody

Abbreviation

FOLH1

Swiss Prot

Q04609 Human

Cellular Locus

Cell membrane, Cytoplasm.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human PSMA aa 30-750/750.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

LNCaP cell lysate, 22RV1 cell lysate, human prostate tissue, human prostate cancer tissue, human kidney tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,000

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 84 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

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