MICA Mouse Monoclonal Antibody [A4C5]
MHC class I polypeptide–related sequence A (MICA) is a highly polymorphic cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and it has similar domain structure, however, it is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do. MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D"). MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface and which are activated via this interaction.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
MIC-A MHC class I polypeptide-related sequence A
Swiss Prot
Q29983 Human
Cellular Locus
Cell membrane, Cytoplasm, Membrane.
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within human MICA aa 200-300.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB
Positive Control
MCF-7 cell lysate, Hela cell lysate.
Concentration
2 mg/mL
Dilution
WB: 1:500-1:1,000
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 43 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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