Cytokeratin 5+6 Rabbit Polyclonal Antibody
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin (KRT5) is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
KRT5, KRT6A, KRT6B, KRT6C
Swiss Prot
P13647 Human, P02538 Human, P04259 Human, P48668 Human
Cellular Locus
Intermediate filament, Keratin.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human Cytokeratin 5 aa 191-240.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Human skin tissue lysate, A431 cell lysate, human tonsil tissue, human lung adenocarcinoma tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:600
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
62/60 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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