CRLF2 Rabbit Polyclonal Antibody
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Product Specifications
Product Name Alternative
Abbreviation
CRLF2
Swiss Prot
Q9HC73 Human
Cellular Locus
Cell membrane; Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human CRLF2 aa 301-350.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
THP-1 cell lysate, HepG2 cell lysate, Jurkat cell lysate, 293 cell lysate, human endometrium tissue, A431, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:1,000;IF-Cell: 1:200;IHC-P: 1:600
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 42 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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