GSDMA Rabbit Polyclonal Antibody
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)- bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. The physiological relevance of these observations is unknown (Probable).
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
GSDMA
Swiss Prot
Q96QA5 Human,
Cellular Locus
Cytosol, perinuclear region; Cell membrane.
Host
Rabbit
Species Reactivity
Human,Rat
Immunogen
Recombinant protein within human GSDMA aa 1-200.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
Human skin tissue lysate, rat skin tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 49 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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