WDR77 Rabbit Polyclonal Antibody
Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene. Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
WDR77
Swiss Prot
Q9BQA1 Human
Cellular Locus
Nucleus, Cytoplasm.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human WDR77 aa 1-342 / 342.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
HepG2 cell lysate, Daudi cell lysate, Hela cell lysate, 293 cell lysate, K562 cell lysate, Hela, HepG2.
Concentration
2 mg/mL
Dilution
WB: 1:1,000;IF-Cell: 1:200;FC: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 37 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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