IL-6R Rabbit Polyclonal Antibody
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
IL6R
Swiss Prot
P08887 Human
Cellular Locus
Cell membrane, Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human IL-6R aa 20-69/468.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Daudi cell lysate, A549 cell lysate, K562 cell lysate, Hela, human fetal skeletal muscle tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000;IF-Cell: 1:200;IHC-P: 1:600
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 52 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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