Frizzled 7 Rabbit Polyclonal Antibody
Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. Fz-7 has been shown to interact with DLG4.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
FZD7
Swiss Prot
O75084 Human
Cellular Locus
Cell membrane, Endosome membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human Frizzled 7 aa 525-574 / 574.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
HepG2 cell lysate, 293 cell lysate, 293T cell lysate, human skeletal muscle tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 64 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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