SKP2 Rabbit Polyclonal Antibody
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene. Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-140 position and the C-terminal region forming a concave surface consisting of ten leucine-rich repeats (LRRs). The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which often—but not always—recognize substrates in a phosphorylation-dependent manner. In this SCF complex, Skp2 acts as the substrate recognition factor.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
SKP2
Swiss Prot
Q13309 Human
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human SKP2 aa 1-150 / 424.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
Siha cell lysate, HepG2 cell lysate, 293T cell lysate, HeLa, human placenta tissue.
Concentration
1.783 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:400 ;IF-Cell: 1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 46/48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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