TAB3 Rabbit Polyclonal Antibody
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
TAB3, MAP3K7IP3
Swiss Prot
Q8N5C8 Human, Q571K4 Mouse
Cellular Locus
Cytosol, extracellular exosome, plasma membrane.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within Human TAB3 aa 513-712 / 712.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
NIH/3T3 cell lysates, human striated muscle tissue.
Concentration
1.854 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:600
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 79 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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