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RYBP Rabbit Polyclonal Antibody

The products of the Polycomb group (PcG) of genes are necessary for the maintenance of transcriptional repression of a number of important developmental genes, including the homeotic genes. RYBP is a member of the mammalian polycomb complex. RYBP (RING1- and YY1-binding protein) interacts specifically with the E2F2 and E2F3 family members, dependent on the marked box domain in these proteins. YY1 and RYBP, in combination with either E2F2 or E2F3, can stimulate Cdc6 promoter activity synergistically, at G1/S of the cell cycle. RYBP also complexes with both RING1 proteins (RING1 and RING1B) and with M33, two mutually interacting sets of proteins of the mammalian Polycomb complex. RING1 binds RYBP and M33 through the same C-terminal domain, whereas the RYBP-M33 interaction takes place through an M33 domain not involved in binding.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

2410018J24Rik antibody AAP 1 antibody AAP1 antibody APAP 1 antibody APAP-1 antibody APAP1 antibody Apoptin associating protein 1 antibody Apoptin-associating protein 1 antibody cb337 antibody Death effector domain associated factor antibody Death effector domain-associated factor antibody Death effector domain-associated factor B antibody DED associated factor antibody DED-associated factor antibody DED-associated factor B antibody DEDAF antibody MGC62213 antibody RING1 and YY1 binding protein a antibody RING1 and YY1 binding protein antibody RING1 and YY1-binding protein antibody RING1 and YY1-binding protein B antibody Ring1 interactor RYBP antibody RYBP antibody RYBP_HUMAN antibody rybpa antibody wu:fi34f03 antibody YEAF 1 antibody YEAF1 antibody YY1 and E4TF1 associated factor 1 antibody YY1 and E4TF1-associated factor 1 antibody YY1- and E4TF1/GABP-associated factor 1 antibody zgc:153842 antibody

Abbreviation

RYBP

Swiss Prot

Q8N488 Human, Q8CCI5 Mouse,

Cellular Locus

Cytoplasm, nucleus, nucleoplasm.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant protein within Human RYBP aa 1-200 / 228.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB

Positive Control

SH-SY5Y cell lysate, mouse brain tissue lysate, rat kidney tissue lysate, rat brain tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 25 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No

Frequently Asked Questions

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