RYBP Rabbit Polyclonal Antibody
The products of the Polycomb group (PcG) of genes are necessary for the maintenance of transcriptional repression of a number of important developmental genes, including the homeotic genes. RYBP is a member of the mammalian polycomb complex. RYBP (RING1- and YY1-binding protein) interacts specifically with the E2F2 and E2F3 family members, dependent on the marked box domain in these proteins. YY1 and RYBP, in combination with either E2F2 or E2F3, can stimulate Cdc6 promoter activity synergistically, at G1/S of the cell cycle. RYBP also complexes with both RING1 proteins (RING1 and RING1B) and with M33, two mutually interacting sets of proteins of the mammalian Polycomb complex. RING1 binds RYBP and M33 through the same C-terminal domain, whereas the RYBP-M33 interaction takes place through an M33 domain not involved in binding.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
RYBP
Swiss Prot
Q8N488 Human, Q8CCI5 Mouse,
Cellular Locus
Cytoplasm, nucleus, nucleoplasm.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human RYBP aa 1-200 / 228.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
SH-SY5Y cell lysate, mouse brain tissue lysate, rat kidney tissue lysate, rat brain tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 25 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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