TNFR2 Rabbit Polyclonal Antibody
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Product Specifications
Product Name Alternative
Abbreviation
TNFRSF1B
Swiss Prot
P20333 Human, P25119 Mouse, Q80WY6 Rat
Cellular Locus
Cell membrane, Secreted.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human TNFR2 aa 20-461 / 461.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IHC-P, FC
Positive Control
Rat epididymis tissue, human uterus tissue, mouse testis tissue, HepG2.
Concentration
1 mg/mL
Dilution
IHC-P:1:50-1:100 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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