CX3CL1 Rabbit Polyclonal Antibody
Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 . Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 . The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Processed fractalkine C-X3-C motif chemokine 1 CX3C membrane-anchored chemokine Neurotactin Fractalkine Small-inducible cytokine D1
Swiss Prot
P78423 Human
Cellular Locus
Cell membrane, Membrane, Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human CX3CL1 aa 25-341 / 397 (Extracellular).
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
SK-BR-3 cell lysate, HepG2 cell lysate, human skin tissue, human breast carcinoma tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
42 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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