NEDD1 Rabbit Polyclonal Antibody

NEDD1 (neural precursor cell expressed, developmentally down-regulated 1), also known as GCP-WD, is a homolog of the Drosophila protein known as Dgp71WD. It is a ubiquitously expressed, evolutionarily conserved protein and contains eight WD40 repeats and a coiled coil domain at the C-terminus. NEDD1 is a subunit of the γ-tubulin ring complex (γTuRC) and plays an important role in mitosis. During mitosis NEDD1 is phosphorylated and functions in forming the association of γ-tubulin with the spindle. The state of phosphorylation of NEDD1 is also important for determining its cellular localization. NEDD1 is responsible for targeting γTuRC to the centrosome and spindle and is therefore required for centrosomal and chromatin-mediated microtubule nucleation. The inhibition of NEDD1 results in the loss of γTuRC from the centrosome and a sequential loss of microtubule nucleation. Due to its critical role in mitosis, NEDD1 may be a potential target for anticancer therapies.