GLP-1R Rabbit Polyclonal Antibody
Selected Variant
HA500204
Size: 100 µL
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
GLP1R
Swiss Prot
P43220 Human, O35659 Mouse, P32301 Rat
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human GLP-1R aa 24-175.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
Mouse stomach tissue lysates, SH-SY5Y cell lysate, rat stomach tissue lysate, SH-SY5Y, rat pancreas tissue, human pancreas tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IHC-P: 1:100-1:500;IF-Cell: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
predicted 53 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Price
Frequently Asked Questions
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