CCR3 Rabbit Polyclonal Antibody
Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES (CCL5) and CCL15 . Subsequently transduces a signal by increasing the intracellular calcium ions level . In addition acts as a possible functional receptor for NARS1 . (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
C-C chemokine receptor type 3 C C CKR3 C-C CKR-3 CC-CKR-3 CCR-3 CCR3 CKR 3 CKR3 Eosinophil eotaxin receptor CD193
Swiss Prot
P51677 Human, P51678 Mouse, O54814 Rat
Cellular Locus
Cell membrane, Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within C-termina human CCR3.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
Rat lung tissue lysate, human liver tissue lysate, mouse liver tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 43 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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