Phospholamban Rabbit Polyclonal Antibody
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca (2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Cardiac phospholamban antibody CMD1P antibody CMH18 antibody PLB antibody Pln antibody PPLA_HUMAN antibody PLN
Abbreviation
PLN
Swiss Prot
P26678 Human, P61014 Mouse, P61016 Rat
Cellular Locus
Endoplasmic reticulum membrane, Mitochondrion membrane, Sarcoplasmic reticulum membrane, Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within human Phospholamban aa 1-31.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Rat heart tissue lysate, human heart tissue lysate, SH-SY5Y, rat heart tissue, human fetal skeletal muscle tissue, mouse heart tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IF-Cell: 1:50-1:100;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 6 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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