SMURF1 Rabbit Polyclonal Antibody
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Plays a role in dendrite formation by melanocytes .
Product Specifications
Product Name Alternative
Abbreviation
Swiss Prot
Q9HCE7 Human, Q9CUN6 Mouse
Cellular Locus
Cell membrane, Cytoplasm, Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within human SMURF1 aa 30-80.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
NIH/3T3 cell lysate, MCF-7 cell lysate, rat kidney tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size:86 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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