GOT2 Recombinant Rabbit Monoclonal Antibody [JE54-46]

Aspartate aminotransferase, mitochondrial is an enzyme that in humans is encoded by the GOT2 gene. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. Also, GOT2 is a major participant in the malate-aspartate shuttle, which is a passage from the cytosol to the mitochondria. The two enzymes are homodimeric and show close homology. GOT2 has been seen to have a role in cell proliferation, especially in terms of tumor growth. GOT2 and another enzyme, MDH, are essential for the functioning of the shuttle. GOT2 converts oxaloacetate into aspartate by transamination. This aspartate as well as alpha-ketoglutarate return into the cytosol, which is then converted back to oxaloacetate and glutamate, respectively. Another function of GOT2 is that it is believed to transaminate kynurenine into kynurenic acid (KYNA) in the brain. The KYNA made by the GOT2 is thought to be an important factor in brain pathology.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

AATM_HUMAN antibody AL022787 antibody Aspartate aminotransferase 2 antibody Aspartate aminotransferase antibody Aspartate aminotransferase, mitochondrial antibody Aspartate transaminase 2 antibody ASPATA antibody EC 2.6.1.1 antibody FABP 1 antibody FABP pm antibody FABP-1 antibody FABPpm antibody Fatty acid binding protein antibody Fatty acid-binding protein antibody FLJ40994 antibody Glutamate oxaloacetate transaminase 2 antibody Glutamate oxaloacetate transaminase 2, mitochondrial antibody Glutamate oxaloacetate transaminase, mitochondrial antibody Glutamic oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) antibody Got 2 antibody GOT2 antibody KAT4 antibody KATIV antibody kynurenine aminotransferase 4 antibody Kynurenine aminotransferase IV antibody kynurenine--oxoglutarate transaminase 4 antibody kynurenine--oxoglutarate transaminase IV antibody mAspAT antibody MGC102129 antibody MGC115763 antibody mitAAT antibody mitochondrial antibody Mitochondrial aspartate aminotransferase antibody OTTMUSP00000017748 antibody Plasma membrane fatty acid binding protein antibody Plasma membrane-associated fatty acid-binding protein antibody Transaminase A antibody

Abbreviation

GOT2

Swiss Prot

P00505 Human, P05202 Mouse, P00507 Rat,Q7SYK7 DANRE

Cellular Locus

Cell membrane, mitochondrion matrix.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Zebrafish

Immunogen

Recombinant protein within Human GOT2 aa 1-139 / 430.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Rat brain tissue lysate, mouse brain tissue lysate, zebrafish tissue lysates, rat smooth muscle tissue, human liver tissue, human colon carcinoma tissue, mouse kidney tissue, SiHa.