SPAK Recombinant Rabbit Monoclonal Antibody [JE53-64]
STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene. This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Some studies suggest that this gene might be linked to high blood pressure.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
STK39
Swiss Prot
Q9UEW8 Human
Cellular Locus
Nucleus, cytoplasm.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human SPAK aa 361-545 / 545.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Jurkat cell lysate, HepG2 cell lysate, human prostate carcinoma tissue, human pancreas tissue, Daudi.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 59 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
