Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Phospho-HER3/ErbB3 (Y1222) Recombinant Rabbit Monoclonal Antibody [JE51-89]

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

c erbB 3 antibody c erbB3 antibody Erb b2 receptor tyrosine kinase 3 antibody ErbB 3 antibody ERBB3 antibody ERBB3 protein antibody erbB3 S antibody ERBB3_HUMAN antibody Glial growth factor receptor antibody HER 3 antibody HER3 antibody Human epidermal growth factor receptor 3 antibody LCCS2 antibody MDA BF 1 antibody MGC88033 antibody p180 ErbB3 antibody p45 sErbB3 antibody p85 sErbB3 antibody proto-oncogene-like protein c ErbB 3 antibody proto-oncogene-like protein c ErbB3 antibody Proto-oncogene-like protein c-ErbB-3 antibody Receptor tyrosine protein kinase erbB 3 antibody Receptor tyrosine protein kinase erbB3 antibody Receptor tyrosine-protein kinase erbB-3 antibody Tyrosine kinase type cell surface receptor HER3 antibody Tyrosine kinase-type cell surface receptor HER3 antibody v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

Abbreviation

ERBB3

Swiss Prot

P21860 Human

Cellular Locus

Cell membrane, secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic phosphopeptide corresponding to a region surrounding Tyrosine 1222 of Human ErbB3.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

MCF7 serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes cell lysate, human thyroid tissue, human skin tissue, human placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 148 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CD50 (ICAM-3) (101-1D2), CF568 conjugate, 0.1mg/mL
BNC680177-500 1x 500 µL

CD50 (ICAM-3) (101-1D2), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
CD3e (CRIS-7), CF568 conjugate, 0.1mg/mL
BNC681050-500 1x 500 µL

CD3e (CRIS-7), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF405S conjugate, 0.1mg/mL
BNC041429-500 1x 500 µL

E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Tyrosinase (T311), CF488A conjugate, 0.1mg/mL
BNC880012-500 1x 500 µL

Tyrosinase (T311), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Cytokeratin 8/18 (C-51), CF568 conjugate, 0.1mg/mL
BNC680034-100 1x 100 µL

Cytokeratin 8/18 (C-51), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Cytokeratin, HMW (AE-3), CF488A conjugate, 0.1mg/mL
BNC880257-100 1x 100 µL

Cytokeratin, HMW (AE-3), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details